{"product_id":"3-sulfas-inyectable","title":"3 Sulfas Injectable","description":"\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e3 SULFAS is an injectable solution made with Sulfamethazine, Sulfamerazine, and Sulfadiazine, whose antibiotic combination offers greater solubility, lower renal toxicity, and a broader antibacterial spectrum of action against gram-positive and gram-negative bacteria that cause digestive, respiratory, genitourinary, mammary gland, musculoskeletal, and septicemic diseases in cattle, horses, sheep, pigs, poultry, and dogs.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAntibiotic\u003c\/strong\u003e\u003cbr\u003eSulfamethazine, sulfamerazine, and sulfadiazine\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eMECHANISM OF ACTION:\u003c\/strong\u003e 3 SULFAS have a mechanism of action based on occupying para-aminobenzoic acid (PABA) receptors, preventing bacteria from incorporating folic acid and the growth factors they require and cannot synthesize into their metabolism. Additionally, they inhibit aerobic and anaerobic bacterial respiration.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePHARMACOKINETICS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhen 3 SULFAS are administered parenterally or orally, they show excellent absorption. They enter the bloodstream, are distributed throughout the body, and bind to plasma albumin, rapidly diffusing to reach high concentrations in extravascular fluids, allowing them to eliminate bacterial infections, most of which are extravascular. They also diffuse easily into the fetus and fetal membranes, showing lower concentrations in the central nervous system, bones, and adipose tissue. They are metabolized in the liver and excreted by glomerular filtration and tubular secretion in the kidneys, with smaller amounts eliminated in feces, bile, pancreatic juice, gastric juice, saliva, and milk.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIMPORTANCE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe importance of 3 SULFAS lies in the combination of the contained SULFAS, which provides greater solubility, better absorption, lower renal toxic effect, and a broader antibacterial spectrum of action against gram-positive and gram-negative bacteria that cause digestive, respiratory, genitourinary, mammary gland, musculoskeletal, and septicemic diseases in cattle, horses, sheep, pigs, poultry, and dogs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e3 SULFAS are indicated for the treatment of respiratory tract infections (pneumonia, bronchopneumonia, etc.), gastrointestinal tract infections (colibacillosis), upper and lower urinary tract infections, genital tract infections (septic metritis, retained placenta), musculoskeletal system infections (foot rot), mammary gland infections (acute and chronic mastitis), and other infections affecting cattle, sheep, goats, swine (hemorrhagic septicemia, necrotic enteritis), canines (pneumonia, bacillary diarrhea, and complications of canine distemper), and poultry (coccidiosis, salmonellosis, and fowl cholera).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eADMINISTRATION ROUTE AND DOSAGE:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"font-weight: 400;\"\u003eIntravenous: In cattle, horses, sheep, goats, \u003c\/span\u003eand dogs.\u003c\/li\u003e\n\u003cli\u003eIntramuscular: In pigs\u003c\/li\u003e\n\u003cli\u003eOral in drinking water: In poultry\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe dose depends on the specific case; however, in general terms, the recommended dose is:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHorses and Cattle:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e50 mL of 3 SULFAS per 100 kg intravenously (100 mg\/kg of weight).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePigs, Sheep, and Goats:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e7 mL of 3 SULFAS per 10 kg (140 mg\/kg of weight).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIn Dogs and Cats:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e3.5 to 7 mL of 3 SULFAS per 10 kg via slow intravenous injection (70 - 140 mg per kg of weight).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIn poultry, the dose will depend on the administration route:\u003c\/strong\u003e Intramuscular: 0.5 mL of 3 SULFAS per 1 kg. Drinking water: 5 mL of 3 SULFAS per liter of drinking water for 2 to 3 days of treatment, followed by a break of 2 to 3 days and repeating the administration for 2 to 3 more days. Respiratory problems: 100 mg\/kg. Digestive problems: 50 mg\/kg of weight.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eCONTRAINDICATIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eShould not be used in animals showing liver damage, kidney damage, blood dyscrasias, or a history of hypersensitivity to sulfonamides.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDo not use in horses intended for human consumption. Due to its potential to crystallize urine, it is advisable to avoid its use in dogs with a history of urolithiasis or at high risk of developing urolithiasis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eADVERSE EFFECTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn dogs, keratoconjunctivitis sicca (which may not be reversible), acute neutrophilic hepatitis, anorexia, diarrhea, fever, hemolytic anemia, urticaria, polyarthritis, facial swelling, \u003c\/span\u003epolydipsia, polyuria, and cholestasis may occur. Potentiated sulfonamides can cause hypothyroidism in dogs, particularly with extended therapies. Acute type I or type II hypersensitivity reactions may occur in rare cases. Other hematological effects (anemia, \u003cb\u003e \u003c\/b\u003e\u003cspan\u003eagranulocytosis) are possible but very rare. Adverse effects in cats may include \u003c\/span\u003e\u003cspan\u003eanorexia, leukopenia, and anemia. In horses, transient pruritus may occur after intravenous administration.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eOVERDOSAGE\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eManifestations of overdose may include gastrointestinal clinical signs (nausea, vomiting, diarrhea), CNS toxicity (depression, headache, and confusion), facial swelling, bone marrow aplasia, and increased serum aminotransferases. Blood cell counts should be constantly monitored.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eDRUG INTERACTIONS\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe use of antacids may decrease the bioavailability of sulfonamides if administered concomitantly. Concomitant cyclosporine may increase the \u003c\/span\u003e\u003cspan\u003erisk of toxicity. The use of diuretics may increase the risk of thrombocytopenia.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eSulfonamides can displace methotrexate from plasma proteins and increase the risk of toxic effects. Sulfonamides can prolong the half-life of \u003cb\u003e \u003c\/b\u003e\u003cspan\u003ephenytoin. Sulfonamides can decrease the effectiveness of tricyclic antidepressants. Sulfonamides can prolong INR\/PT times when used with warfarin.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWARNINGS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis product is for exclusive use in veterinary medicine; \u003c\/span\u003e\u003cspan\u003edo not use in humans. Store at a temperature below 25°C and \u003c\/span\u003e\u003cspan\u003eprotected from sunlight. Keep out of reach of children.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWITHDRAWAL PERIOD: \u003c\/b\u003e5 days for meat and milk.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePRESENTATION: \u003c\/b\u003e100, 250, and 500 ml bottles.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFORMULA:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eEach 100 mL contains:\u003c\/p\u003e\n\u003cp\u003eSulfamethazine: 6.66 g, Sulfamerazine: 6.66 g Sulfadiazine: 6.66 g, Sterile distilled water q.s.p: 100.00 ml\u003c\/p\u003e","brand":"PiSA","offers":[{"title":"500 mL","offer_id":61742002602354,"sku":null,"price":490.0,"currency_code":"MXN","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0970\/3869\/6818\/files\/3-sulfas-inyectable.png?v=1775509491","url":"https:\/\/farmabio.org\/en\/products\/3-sulfas-inyectable","provider":"Farmabio Insumos Veterinarios","version":"1.0","type":"link"}