{"product_id":"napzin-meglumina-de-flunixin","title":"NAPZIN Flunixin Meglumine","description":"\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eNAPZIN is an injectable non-steroidal analgesic, anti-inflammatory, and antipyretic drug indicated for the treatment of endotoxemia and as an aid in the treatment of respiratory diseases, as well as skeletal and smooth muscle disorders (muscle trauma, joint trauma, colic, mastitis, postsurgical procedures, blows, etc.), in cattle, sheep, goats, horses, swine, dogs, and cats. It is not immunosuppressive and can be administered to animals of any age.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eINDICATIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIn females at parturition\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePrevents febrile states, pain, or discomfort in freshly calved females, promoting their rapid recovery and increasing milk production from the mammary gland without inflammation.\u003c\/li\u003e\n\u003cli\u003eReduces inflammation in the female reproductive tract, promoting better blood circulation, improved tissue oxygenation, and the arrival of defense and repair blood cells. Improves colostrum secretion during the first 5 hours after application (postpartum), thanks to better circulation and oxygenation of the mammary gland, as well as the correct arrival of oxytocin secreted by the pituitary gland.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eCattle\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor the treatment of endotoxemia, acute or chronic respiratory diseases, acute mastitis, and pododermatitis, as well as an adjuvant in downer cow syndrome, in the control of infectious and\/or mechanical diarrheas in calves.\u003c\/li\u003e\n\u003cli\u003eIt is also indicated for alleviating disorders associated with skeletal muscle and smooth muscle conditions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eHorses\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIndicated for inflammation and pain associated with musculoskeletal disorders (laminitis), in cases of endotoxemia, and for the relief of visceral pain associated with colic, as an adjuvant in the treatment of colitis and in acute respiratory disease.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSwine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"font-weight: 400;\"\u003eFor the treatment of fever, inflammation of the locomotor system (lameness in general) and for \u003c\/span\u003eany type of pain.\u003c\/li\u003e\n\u003cli\u003ePrevents signs and inflammation caused by damage that occurs during the farrowing process within the sow's reproductive tract, whether due to the natural expulsion of piglets or due to dystocia.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eDOSAGE AND ADMINISTRATION\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eThe general dose for all species is 1.1 to 2.2 mg\/kg, intramuscularly (IM) or intravenously (IV) for a period of 12, 24, or 36 hours depending on severity.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHorses\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"font-weight: 400;\"\u003eIn cases of colic, laminitis: \u003cspan\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e1.1 mg\/kg \u003c\/span\u003e\u003c\/span\u003edaily for only 5 days IV or IM\u003c\/li\u003e\n\u003cli\u003eAs an anti-inflammatory and against endotoxemia 0.25 to 0.5 mg\/kg IV.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn horses, the therapeutic response is observed between 15 to 60 minutes after intravenous administration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSwine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWhen NAPZIN \u003cspan\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e®\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eis applied during the first 12 hours after farrowing:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"font-weight: 400;\"\u003eImproved productive state by increasing \u003c\/span\u003eperformance.\u003c\/li\u003e\n\u003cli\u003eImproved milk production.\u003c\/li\u003e\n\u003cli\u003eImproved weaning weight of the litter.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWith the routine application of NAPZIN® after farrowing, greater milk production in sows will be obtained and:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan style=\"font-weight: 400;\"\u003eImproved weight gain in \u003c\/span\u003epiglets (12 to 14 g per day).\u003c\/li\u003e\n\u003cli\u003eReduced litter mortality (0.55 piglet per litter on average).\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eBetter piglet weaning weight (plus 250 to \u003c\/span\u003e270 g)\u003c\/li\u003e\n\u003cli\u003eBetter weight of small piglets (100 g at weaning)\u003c\/li\u003e\n\u003cli\u003eBetter litter weaning weight (5.5 to 6.28 kg)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eSmall animal species\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDogs\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn dogs, the dose is 0.5 to 2.2 mg\/kg IM or IV every 24 hours for a maximum of 2 days.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFor ocular diseases 0.5 mg\/kg every 12 hours (1 to 2 treatments)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFor surgical pain 1 mg\/kg IV or IM\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTo control fever (pyrexia) 0.25mg\/kg\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCats\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn cats, 0.25 mg\/kg SC every 24h, repeat treatment only if necessary once more.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePRESENTATIONS:\u003c\/strong\u003e 100 ml, 250 ml\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003ePHYSICAL AND CHEMICAL CHARACTERISTICS:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eIt belongs to the group of non-steroidal anti-inflammatory drugs and is a nicotinic acid substitute, it is \u003c\/span\u003eunique in its chemical structure and it is recommended to store it between 2 and 30° C. It is characterized by its high degree of conjugation to plasma proteins, this situation explains the high concentration of the drug in inflammatory fluids due to the extravasation of proteins and fluids from the bloodstream and the acidic pH of the inflammation area.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eMECHANISM OF ACTION NAPZIN®\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eacts by inhibiting cyclooxygenase enzymes of the arachidonic acid cascade, suppressing the production of certain chemical mediators (histamine, proteolytic enzymes, etc.) which are involved in the inflammatory process, thus manifesting its analgesic, antipyretic, and anti-inflammatory properties. At low doses, it also reduces thromboxanes (TXs) and prostaglandins (PG12), decreasing signs of endotoxemia, making it an excellent alternative for colic in horses.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePHARMACOKINETICS: \u003c\/b\u003eFlunixin Meglumine is rapidly absorbed after parenteral administration. Its volume of distribution is 0.43 to 0.49 L\/kg, and its half-life is 5.7 to 6.2 hours. Plasma levels are reached within 5 to 10 minutes after application, so its effect manifests immediately. It has a high degree of conjugation to plasma proteins, favoring its concentration in the inflammation area. It is excreted in feces, urine, and in very small amounts in milk.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUSE DURING GESTATION, LACTATION OR LAYING\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePost-marketing studies in cattle have shown that the use of the product within the first 36 hours after calving leads to a higher incidence of retained placenta. The product should only be administered within the first 36 hours postpartum, after an adequate evaluation by the veterinarian. Treated animals should be monitored to avoid cases of retained placenta.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eDo not administer to pregnant mares or sows.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eINTERACTIONS WITH OTHER MEDICATIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIt is preferable not to administer NAPZIN to animals under general anesthesia until their complete recovery.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCONTRAINDICATIONS:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDo not use in animals suffering from heart, liver, or kidney disease, when there is a possibility of gastrointestinal ulceration or bleeding or when there is evidence of blood dyscrasia. Do not use in animals suffering from colic caused by ileus and associated with dehydration. Do not use in animals suffering from chronic musculoskeletal disorders. Do not use in animals with known hypersensitivity to the active ingredient. Do not use in mares producing milk for human consumption. Do not administer to pregnant mares or sows. Do not use the product within 48 hours prior to the expected date of bovine parturition. Do not administer to breeding sows, breeding pigs, and piglets weighing less than 6 kg.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eOVERDOSAGE\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eOverdose is associated with gastrointestinal toxicity\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWARNINGS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis product is for exclusive use in \u003cspan\u003eveterinary medicine. \u003c\/span\u003eStore in a cool place. Keep out of reach of children.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWITHDRAWAL PERIOD\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn cattle, meat withdrawal is 24 hours and milk withdrawal is \u003c\/span\u003e\u003cspan\u003e12 hours after the last application. In swine, meat withdrawal is 21 days after the last application.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eConsult your veterinarian\u003c\/span\u003e\u003c\/p\u003e\n\u003c!----\u003e","brand":"PiSA","offers":[{"title":"100 ml","offer_id":61742003749234,"sku":null,"price":460.0,"currency_code":"MXN","in_stock":true},{"title":"250 mL","offer_id":61742003782002,"sku":null,"price":850.0,"currency_code":"MXN","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0970\/3869\/6818\/files\/napzin_optimized.jpg?v=1775497482","url":"https:\/\/farmabio.org\/en\/products\/napzin-meglumina-de-flunixin","provider":"Farmabio Insumos Veterinarios","version":"1.0","type":"link"}