{"product_id":"pisadrax","title":"Pisadrax","description":"\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePISADRAX®\u003c\/strong\u003e is an injectable macrolide antibiotic, characterized by its efficacy, prolonged activity, and slow elimination, used for the treatment of bovine respiratory disease and bovine infectious keratoconjunctivitis; as well as in the treatment of porcine respiratory disease.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eFORMULA:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eEach mL contains: Tulathromycin Excipients q.s.p.\u003cbr\u003e100.0 mg. 1.0 mL.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePHYSICO-CHEMICAL CHARACTERISTICS:\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e\u003cstrong\u003ePISADRAX®\u003c\/strong\u003e is a semi-synthetic macrolide antimicrobial agent, structurally unique in that it has three amino groups, therefore, it has been given the chemical designation of “triamilide” subclass.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMECHANISM OF ACTION:\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eMacrolides are bacteriostatic antibiotics and inhibit the biosynthesis of essential proteins by selectively binding to bacterial ribosomal RNA. They act by stimulating the dissociation of peptidyl-rRNA from the ribosome during translocation processes.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePHARMACOKINETICS:\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e\u003cstrong\u003ePISADRAX®\u003c\/strong\u003e, when administered to cattle, is characterized by rapid absorption from the injection site, extensive tissue distribution, and slow elimination, which collectively contribute to high and sustained lung concentrations.\u003cbr\u003e\u003cbr\u003eIn cattle after subcutaneous administration, Tulathromycin is rapidly and almost completely absorbed (bioavailability \u003e 90%). The volume of distribution is very large (approximately 11L\/kg); this extensive volume of distribution is largely responsible for the long elimination half-life of the compound. In plasma, the elimination half-life is approximately 2.75 days, but in lung tissue, it is approximately 8.75 days. PISADRAX® is primarily eliminated unchanged through biliary excretion.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eINDICATIONS PER SPECIES:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e\u003cstrong\u003ePISADRAX®\u003c\/strong\u003e is indicated in the treatment and management of beef cattle with bovine respiratory disease associated with \u003cem\u003eMannheimia haemolytica, Pasteurella multocida, Histophilus somni (Haemophilus somnus), and Mycoplasma bovis\u003c\/em\u003e. Treatment of interdigital necrobacillosis associated with Fusobacterium necrophorum and Porphyromonas levii. And as a treatment for Bovine Infectious Keratoconjunctivitis (BIK) associated with Moraxella bovis.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eROUTE OF ADMINISTRATION.\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eIn cattle, the recommended route of administration is subcutaneous in the neck region.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eDOSAGE:\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eBeef cattle: administer 2.5 mg\/kg of body weight, equivalent to 1 mL of PISADRAX® per 40 kg of body weight, as a single injection.\u003cbr\u003e\u003cbr\u003e\u003cimg alt=\"\" src=\"https:\/\/www.pecuarios.club\/uploads\/Upload-6230dd2e3343c-15032022.jpeg\"\u003e\u003cbr\u003e\u003cbr\u003eIf clinical signs of respiratory disease persist after 48 hours, it is suggested to change the treatment using another antibiotic until the signs disappear.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eCONTRAINDICATIONS:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eContraindicated in animals with hypersensitivity to macrolide antibiotics.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eShould not be administered to dairy cows 20 months of age or older.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eDo not use in calves intended for veal.\u003c\/span\u003e\u003cbr\u003e \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eOVERDOSAGE:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eIn cattle, at doses three, five, or ten times the recommended dose, transient signs attributed to discomfort at the injection site were observed.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eDRUG INTERACTIONS:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eCross-resistance exists with other macrolides. Do not administer simultaneously with antimicrobials with a similar mode of action, such as other macrolides or lincosamides.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eWARNINGS\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eProduct for exclusive use in veterinary medicine, not for human use.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eKeep out of reach of children.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eStore at room temperature not exceeding 30°C.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDo not administer to cattle whose milk is intended for human consumption.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eOnce opened, the product must be used within 30 days.\u003c\/span\u003e\u003cbr\u003e \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePRECAUTIONS\u003c\/strong\u003e:\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eIn cattle, do not inject more than 7.5 mL per injection site.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eWITHDRAWAL PERIOD:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eBeef cattle: 18 days\u003cbr\u003eIts use is not intended for cattle whose milk is for human consumption.\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePRESENTATION:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eOne bottle with 20 mL, 50 mL, 100 mL, 250 mL, and 500 mL.\u003cbr\u003e\u003cstrong\u003eConsult a Veterinary Zootechnician\u003c\/strong\u003e\u003cbr\u003eInformation exclusive for Veterinary Zootechnicians.\u003cbr\u003e\u003cstrong\u003eRequires a prescription for sale.\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCONSULT A VETERINARY ZOOTECHNICIAN\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\u003cem\u003e\u003cspan\u003eAny adverse reaction should be reported to the Veterinary Pharmacovigilance Unit of PiSA Agropecuaria.\u003c\/span\u003e\u003c\/em\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003e\u003cspan\u003eContent responsible.\u003cbr\u003eTechnical Department, PiSA Agropecuaria S.A. de C.V.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/em\u003e\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eComparative pharmacokinetic test\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eAt the PiSA AGROPECUARIA experimental ranch, a comparative, randomized controlled, prospective, single-blind study was conducted evaluating the Pisadrax® treatment (Tulathromycin 100 mg\/mL from PiSA AGROPECUARIA) vs. treatment with a reference product (Tulathromycin 100 mg\/mL patented product) comparing pharmacokinetic variables at a dose of 2.5 mg\/kg of body weight.\u003cbr\u003e\u003cbr\u003eSix male cattle were selected per treatment group, of similar phenotype and breed, approximately 10 months old, to which a dose of Tulathromycin was administered subcutaneously, according to label indications. Blood samples were taken during the period determined in the test, and subsequently, the plasma concentration of Tulathromycin for each treatment group was evaluated.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"https:\/\/www.pecuarios.club\/uploads\/Upload-624357aed65ba-29032022.jpeg\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe results in Table 1 show that the pharmacokinetic values of the plasma concentration of the Pisadrax® product are statistically similar to those of the reference product, as there was no significant statistical difference in the values obtained. Therefore, it is expected that, in everyday treatment situations or metaphylaxis in high-risk cattle, in a production unit, the performance of Pisadrax® will be the same as that of the reference product.\u003c\/span\u003e\u003c\/p\u003e","brand":"PiSA","offers":[{"title":"100 mL","offer_id":61742001127794,"sku":null,"price":1990.0,"currency_code":"MXN","in_stock":true},{"title":"250 mL","offer_id":61742001160562,"sku":null,"price":3950.0,"currency_code":"MXN","in_stock":true},{"title":"500 mL","offer_id":61742001193330,"sku":null,"price":7200.0,"currency_code":"MXN","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0970\/3869\/6818\/files\/Pisadrax_100ml.jpg?v=1777039671","url":"https:\/\/farmabio.org\/en\/products\/pisadrax","provider":"Farmabio Insumos Veterinarios","version":"1.0","type":"link"}