NAPZIN Flunixin Meglumine

NAPZIN is an injectable non-steroidal analgesic, anti-inflammatory, and antipyretic drug indicated for the treatment of endotoxemia and as an aid in the treatment of respiratory diseases, as well as skeletal and smooth muscle disorders (muscle trauma, joint trauma, colic, mastitis, postsurgical procedures, blows, etc.), in cattle, sheep, goats, horses, swine, dogs, and cats. It is not immunosuppressive and can be administered to animals of any age.

INDICATIONS

In females at parturition

• Prevents febrile states, pain, or discomfort in freshly calved females, promoting their rapid recovery and increasing milk production from the mammary gland without inflammation.
• Reduces inflammation in the female reproductive tract, promoting better blood circulation, improved tissue oxygenation, and the arrival of defense and repair blood cells. Improves colostrum secretion during the first 5 hours after application (postpartum), thanks to better circulation and oxygenation of the mammary gland, as well as the correct arrival of oxytocin secreted by the pituitary gland.

Cattle

• For the treatment of endotoxemia, acute or chronic respiratory diseases, acute mastitis, and pododermatitis, as well as an adjuvant in downer cow syndrome, in the control of infectious and/or mechanical diarrheas in calves.
• It is also indicated for alleviating disorders associated with skeletal muscle and smooth muscle conditions.

Horses

• Indicated for inflammation and pain associated with musculoskeletal disorders (laminitis), in cases of endotoxemia, and for the relief of visceral pain associated with colic, as an adjuvant in the treatment of colitis and in acute respiratory disease.

Swine

• For the treatment of fever, inflammation of the locomotor system (lameness in general) and for any type of pain.
• Prevents signs and inflammation caused by damage that occurs during the farrowing process within the sow's reproductive tract, whether due to the natural expulsion of piglets or due to dystocia.

DOSAGE AND ADMINISTRATION

The general dose for all species is 1.1 to 2.2 mg/kg, intramuscularly (IM) or intravenously (IV) for a period of 12, 24, or 36 hours depending on severity.

Horses

• In cases of colic, laminitis:  1.1 mg/kg daily for only 5 days IV or IM
• As an anti-inflammatory and against endotoxemia 0.25 to 0.5 mg/kg IV.

In horses, the therapeutic response is observed between 15 to 60 minutes after intravenous administration.

Swine

When NAPZIN  ® is applied during the first 12 hours after farrowing:

• Improved productive state by increasing performance.
• Improved milk production.
• Improved weaning weight of the litter.

With the routine application of NAPZIN® after farrowing, greater milk production in sows will be obtained and:

• Improved weight gain in piglets (12 to 14 g per day).
• Reduced litter mortality (0.55 piglet per litter on average).
• Better piglet weaning weight (plus 250 to 270 g)
• Better weight of small piglets (100 g at weaning)
• Better litter weaning weight (5.5 to 6.28 kg)

Small animal species

Dogs

In dogs, the dose is 0.5 to 2.2 mg/kg IM or IV every 24 hours for a maximum of 2 days.

For ocular diseases 0.5 mg/kg every 12 hours (1 to 2 treatments)

For surgical pain 1 mg/kg IV or IM

To control fever (pyrexia) 0.25mg/kg

Cats

In cats, 0.25 mg/kg SC every 24h, repeat treatment only if necessary once more.

PRESENTATIONS: 100 ml, 250 ml

PHYSICAL AND CHEMICAL CHARACTERISTICS: It belongs to the group of non-steroidal anti-inflammatory drugs and is a nicotinic acid substitute, it is unique in its chemical structure and it is recommended to store it between 2 and 30° C. It is characterized by its high degree of conjugation to plasma proteins, this situation explains the high concentration of the drug in inflammatory fluids due to the extravasation of proteins and fluids from the bloodstream and the acidic pH of the inflammation area.

MECHANISM OF ACTION NAPZIN® acts by inhibiting cyclooxygenase enzymes of the arachidonic acid cascade, suppressing the production of certain chemical mediators (histamine, proteolytic enzymes, etc.) which are involved in the inflammatory process, thus manifesting its analgesic, antipyretic, and anti-inflammatory properties. At low doses, it also reduces thromboxanes (TXs) and prostaglandins (PG12), decreasing signs of endotoxemia, making it an excellent alternative for colic in horses.

PHARMACOKINETICS: Flunixin Meglumine is rapidly absorbed after parenteral administration. Its volume of distribution is 0.43 to 0.49 L/kg, and its half-life is 5.7 to 6.2 hours. Plasma levels are reached within 5 to 10 minutes after application, so its effect manifests immediately. It has a high degree of conjugation to plasma proteins, favoring its concentration in the inflammation area. It is excreted in feces, urine, and in very small amounts in milk.

USE DURING GESTATION, LACTATION OR LAYING

Post-marketing studies in cattle have shown that the use of the product within the first 36 hours after calving leads to a higher incidence of retained placenta. The product should only be administered within the first 36 hours postpartum, after an adequate evaluation by the veterinarian. Treated animals should be monitored to avoid cases of retained placenta.

Do not administer to pregnant mares or sows.

INTERACTIONS WITH OTHER MEDICATIONS

It is preferable not to administer NAPZIN to animals under general anesthesia until their complete recovery.

CONTRAINDICATIONS:

Do not use in animals suffering from heart, liver, or kidney disease, when there is a possibility of gastrointestinal ulceration or bleeding or when there is evidence of blood dyscrasia. Do not use in animals suffering from colic caused by ileus and associated with dehydration. Do not use in animals suffering from chronic musculoskeletal disorders. Do not use in animals with known hypersensitivity to the active ingredient. Do not use in mares producing milk for human consumption. Do not administer to pregnant mares or sows. Do not use the product within 48 hours prior to the expected date of bovine parturition. Do not administer to breeding sows, breeding pigs, and piglets weighing less than 6 kg.

OVERDOSAGE

Overdose is associated with gastrointestinal toxicity

WARNINGS

This product is for exclusive use in veterinary medicine. Store in a cool place. Keep out of reach of children.

WITHDRAWAL PERIOD

In cattle, meat withdrawal is 24 hours and milk withdrawal is 12 hours after the last application. In swine, meat withdrawal is 21 days after the last application.

Consult your veterinarian